Pathway candidateNCBI-verifiedprotein-coding

PRDX3

peroxiredoxin 3

NCBI Gene: 10935 Ensembl GeneCards UniProt: P30048

Pathway candidate — not linked to PFS or PSSD by any record here

PRDX3 is in the library because it belongs to the mitochondria & energy family. No study, report or commentary in the corpus names it, so a variant in PRDX3 is not, by itself, evidence of anything related to post-drug syndromes.

Gene summary

A protein-coding gene on chromosome 10 (mitochondrial function and energy). Encodes a mitochondrial protein with antioxidant function. The protein is similar to the C22 subunit of Salmonella typhimurium alkylhydroperoxide reductase, and it can rescue bacterial resistance to alkylhydroperoxide in E.

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: Thioredoxin-dependent peroxide reductase, mitochondrial
Function: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides. Acts synergistically with MAP3K13 to regulate the activation of NF-kappa-B in the cytosol. Required for the maintenance of physical strength (By similarity).
Subcellular location: Mitochondrion; Cytoplasm; Early endosome.
Associated conditions: Spinocerebellar ataxia, autosomal recessive, 32 (SCAR32); Corneal dystrophy, punctiform and polychromatic pre-Descemet (PPPCD).

Source: UniProtKB/Swiss-Prot P30048, release 2026_03, licensed CC BY 4.0. This is the protein’s normal biology, not evidence about post-drug syndromes; associated conditions are inherited disorders of the gene, not PFS, PSSD or PRSD.

Why its pathway is in the library

Mitochondrial dysfunction and oxidative stress are reported in PFS/PSSD patient work; energy failure plausibly contributes to fatigue, cognitive, and sexual symptoms.

Written for the whole mitochondria & energy family, not for PRDX3 specifically.

Mentioned in 0 corpus records

No corpus record names PRDX3 directly yet. It is in the library because it sits in a pathway the corpus tracks (Mitochondria & energy).

Also in mitochondrial function and energy

All 33 genes

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Gene summary

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: Thioredoxin-dependent peroxide reductase, mitochondrial
Function: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides. Acts synergistically with MAP3K13 to regulate the activation of NF-kappa-B in the cytosol. Required for the maintenance of physical strength (By similarity).
Subcellular location: Mitochondrion; Cytoplasm; Early endosome.
Associated conditions: Spinocerebellar ataxia, autosomal recessive, 32 (SCAR32); Corneal dystrophy, punctiform and polychromatic pre-Descemet (PPPCD).