Pathway candidateNCBI-verifiedprotein-coding

RAD21

RAD21 cohesin complex component

NCBI Gene: 5885 Ensembl GeneCards UniProt: O60216

Pathway candidate — not linked to PFS or PSSD by any record here

RAD21 is in the library because it belongs to the chromosome cohesion family. No study, report or commentary in the corpus names it, so a variant in RAD21 is not, by itself, evidence of anything related to post-drug syndromes.

Gene summary

A protein-coding gene on chromosome 8 (chromosome cohesion and architecture). The protein encoded by this gene is highly similar to the gene product of Schizosaccharomyces pombe rad21, a gene involved in the repair of DNA double-strand breaks, as well as in chromatid cohesion during mitosis. This protein is a nuclear phospho-protein, which becomes hyperphosphorylated in cell cycle M phase.

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: Double-strand-break repair protein rad21 homolog
Function: Double-strand-break repair protein rad21 homolog: As a member of the cohesin complex, involved in sister chromatid cohesion from the time of DNA replication in S phase to their segregation in mitosis, a function that is essential for proper chromosome segregation, post-replicative DNA repair, and the prevention of inappropriate recombination between repetitive regions. The cohesin complex may also play a role in spindle pole assembly during mitosis. In interphase, cohesins may function in the control of gene expression by binding to numerous sites within the genome (By similarity). May control RUNX1 gene expression (Probable). Binds to and represses APOB gene promoter. May play a role in embryonic gut development, possibly through the regulation of enteric neuron development (By similarity). 64-kDa C-terminal product: May promote apoptosis.
Subcellular location: Nucleus; Nucleus matrix; Chromosome; Chromosome, centromere; Cytoplasm, cytoskeleton, spindle pole; Cytoplasm, cytosol.
Tissue specificity: Expressed in the gut (at protein level).
Associated conditions: Cornelia de Lange syndrome 4 with or without midline brain defects (CDLS4); Mungan syndrome (MGS).

Source: UniProtKB/Swiss-Prot O60216, release 2026_03, licensed CC BY 4.0. This is the protein’s normal biology, not evidence about post-drug syndromes; associated conditions are inherited disorders of the gene, not PFS, PSSD or PRSD.

Why its pathway is in the library

Sister-chromatid cohesion and genome architecture; general cellular function with no direct post-drug-syndrome link established.

Written for the whole chromosome cohesion family, not for RAD21 specifically.

Mentioned in 0 corpus records

No corpus record names RAD21 directly yet. It is in the library because it sits in a pathway the corpus tracks (Chromosome cohesion).

Also in chromosome cohesion and architecture

All 6 genes

Browse by family on the gene families page.

Gene summary

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: Double-strand-break repair protein rad21 homolog
Function: Double-strand-break repair protein rad21 homolog: As a member of the cohesin complex, involved in sister chromatid cohesion from the time of DNA replication in S phase to their segregation in mitosis, a function that is essential for proper chromosome segregation, post-replicative DNA repair, and the prevention of inappropriate recombination between repetitive regions. The cohesin complex may also play a role in spindle pole assembly during mitosis. In interphase, cohesins may function in the control of gene expression by binding to numerous sites within the genome (By similarity). May control RUNX1 gene expression (Probable). Binds to and represses APOB gene promoter. May play a role in embryonic gut development, possibly through the regulation of enteric neuron development (By similarity). 64-kDa C-terminal product: May promote apoptosis.
Subcellular location: Nucleus; Nucleus matrix; Chromosome; Chromosome, centromere; Cytoplasm, cytoskeleton, spindle pole; Cytoplasm, cytosol.
Tissue specificity: Expressed in the gut (at protein level).
Associated conditions: Cornelia de Lange syndrome 4 with or without midline brain defects (CDLS4); Mungan syndrome (MGS).