WAPL
WAPL cohesin release factor
Pathway candidate — not linked to PFS or PSSD by any record here
Gene summary
A protein-coding gene on chromosome 10 (chromosome cohesion and architecture). Enables ATP-dependent protein-DNA unloader activity. Involved in several processes, including mitotic sister chromatid segregation; negative regulation of DNA replication; and negative regulation of sister chromatid cohesion.
Source: NCBI Gene, accessed 2026-10-07.
Protein reference (UniProt)
- Protein
Wings apart-like protein homolog
- Function
Regulator of sister chromatid cohesion in mitosis which negatively regulates cohesin association with chromatin. Involved in both sister chromatid cohesion during interphase and sister-chromatid resolution during early stages of mitosis. Couples DNA replication to sister chromatid cohesion. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair.
- Subcellular location
Nucleus; Chromosome; Cytoplasm.
- Tissue specificity
Isoform 1 is highly expressed in uterine cervix tumor. Isoform 2 is widely expressed with a high level in skeletal muscle and heart.
Source: UniProtKB/Swiss-Prot Q7Z5K2, release 2026_03, licensed CC BY 4.0. This is the protein’s normal biology, not evidence about post-drug syndromes; associated conditions are inherited disorders of the gene, not PFS, PSSD or PRSD.
Why its pathway is in the library
Sister-chromatid cohesion and genome architecture; general cellular function with no direct post-drug-syndrome link established.
Written for the whole chromosome cohesion family, not for WAPL specifically.
Mentioned in 0 corpus records
No corpus record names WAPL directly yet. It is in the library because it sits in a pathway the corpus tracks (Chromosome cohesion).
Also in chromosome cohesion and architecture
All 6 genes- RAD21
RAD21 cohesin complex component
chr 8· Chromosome cohesion· Pathway candidate - SMC1A
structural maintenance of chromosomes 1A
chr X· Chromosome cohesion· Pathway candidate - SMC3
structural maintenance of chromosomes 3
chr 10· Chromosome cohesion· Pathway candidate - STAG1
STAG1 cohesin complex component
chr 3· Chromosome cohesion· Pathway candidate - STAG2
STAG2 cohesin complex component
chr X· Chromosome cohesion· Pathway candidate
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