STAG2
STAG2 cohesin complex component
Pathway candidate — not linked to PFS or PSSD by any record here
Gene summary
A protein-coding gene on chromosome X (chromosome cohesion and architecture). The protein encoded by this gene is a subunit of the cohesin complex, which regulates the separation of sister chromatids during cell division. Targeted inactivation of this gene results in chromatid cohesion defects and aneuploidy, suggesting that genetic disruption of cohesin is a cause of aneuploidy in human cancer.
Source: NCBI Gene, accessed 2026-10-07.
Protein reference (UniProt)
- Protein
Cohesin subunit SA-2
- Function
Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis.
- Subcellular location
Nucleus; Chromosome; Chromosome, centromere.
- Associated conditions
Mullegama-Klein-Martinez syndrome (MKMS); Holoprosencephaly 13, X-linked (HPE13).
Source: UniProtKB/Swiss-Prot Q8N3U4, release 2026_03, licensed CC BY 4.0. This is the protein’s normal biology, not evidence about post-drug syndromes; associated conditions are inherited disorders of the gene, not PFS, PSSD or PRSD.
Why its pathway is in the library
Sister-chromatid cohesion and genome architecture; general cellular function with no direct post-drug-syndrome link established.
Written for the whole chromosome cohesion family, not for STAG2 specifically.
Mentioned in 0 corpus records
No corpus record names STAG2 directly yet. It is in the library because it sits in a pathway the corpus tracks (Chromosome cohesion).
Also in chromosome cohesion and architecture
All 6 genes- RAD21
RAD21 cohesin complex component
chr 8· Chromosome cohesion· Pathway candidate - SMC1A
structural maintenance of chromosomes 1A
chr X· Chromosome cohesion· Pathway candidate - SMC3
structural maintenance of chromosomes 3
chr 10· Chromosome cohesion· Pathway candidate - STAG1
STAG1 cohesin complex component
chr 3· Chromosome cohesion· Pathway candidate - WAPL
WAPL cohesin release factor
chr 10· Chromosome cohesion· Pathway candidate
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