Pathway candidateNCBI-verifiedprotein-coding

SMC3

structural maintenance of chromosomes 3

NCBI Gene: 9126 Ensembl GeneCards UniProt: Q9UQE7

Pathway candidate — not linked to PFS or PSSD by any record here

SMC3 is in the library because it belongs to the chromosome cohesion family. No study, report or commentary in the corpus names it, so a variant in SMC3 is not, by itself, evidence of anything related to post-drug syndromes.

Gene summary

A protein-coding gene on chromosome 10 (chromosome cohesion and architecture). This gene belongs to the SMC3 subfamily of SMC proteins. The protein occurs in certain cell types as either an intracellular, nuclear protein or a secreted protein.

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: Structural maintenance of chromosomes protein 3
Function: Central component of cohesin, a complex required for chromosome cohesion during the cell cycle. The cohesin complex may form a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. Cohesion is coupled to DNA replication and is involved in DNA repair. The cohesin complex also plays an important role in spindle pole assembly during mitosis and in chromosomes movement.
Subcellular location: Nucleus; Chromosome; Chromosome, centromere.
Associated conditions: Cornelia de Lange syndrome 3 with or without midline brain defects (CDLS3).

Source: UniProtKB/Swiss-Prot Q9UQE7, release 2026_03, licensed CC BY 4.0. This is the protein’s normal biology, not evidence about post-drug syndromes; associated conditions are inherited disorders of the gene, not PFS, PSSD or PRSD.

Why its pathway is in the library

Sister-chromatid cohesion and genome architecture; general cellular function with no direct post-drug-syndrome link established.

Written for the whole chromosome cohesion family, not for SMC3 specifically.

Mentioned in 0 corpus records

No corpus record names SMC3 directly yet. It is in the library because it sits in a pathway the corpus tracks (Chromosome cohesion).

Also in chromosome cohesion and architecture

All 6 genes

Browse by family on the gene families page.

Protein reference (UniProt)

Protein: Structural maintenance of chromosomes protein 3
Function: Central component of cohesin, a complex required for chromosome cohesion during the cell cycle. The cohesin complex may form a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. Cohesion is coupled to DNA replication and is involved in DNA repair. The cohesin complex also plays an important role in spindle pole assembly during mitosis and in chromosomes movement.
Subcellular location: Nucleus; Chromosome; Chromosome, centromere.
Associated conditions: Cornelia de Lange syndrome 3 with or without midline brain defects (CDLS3).