Pathway candidateNCBI-verifiedprotein-coding

STAG1

STAG1 cohesin complex component

NCBI Gene: 10274 Ensembl GeneCards UniProt: Q8WVM7

Pathway candidate — not linked to PFS or PSSD by any record here

STAG1 is in the library because it belongs to the chromosome cohesion family. No study, report or commentary in the corpus names it, so a variant in STAG1 is not, by itself, evidence of anything related to post-drug syndromes.

Gene summary

A protein-coding gene on chromosome 3 (chromosome cohesion and architecture). A member of the SCC3 family, expressed in the nucleus. Encodes a component of cohesin, a multisubunit protein complex that provides sister chromatid cohesion along the length of a chromosome from DNA replication through prophase and prometaphase, after which it is dissociated in preparation for segregation during anaphase.

Source: NCBI Gene, accessed 2026-10-10; corrected that day, as the page had carried PMEPA1's record.

Protein reference (UniProt)

Protein: Cohesin subunit SA-1
Function: Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis.
Subcellular location: Nucleus; Chromosome; Chromosome, centromere.
Associated conditions: Intellectual developmental disorder, autosomal dominant 47 (MRD47).

Source: UniProtKB/Swiss-Prot Q8WVM7, release 2026_03, licensed CC BY 4.0. This is the protein’s normal biology, not evidence about post-drug syndromes; associated conditions are inherited disorders of the gene, not PFS, PSSD or PRSD.

Why its pathway is in the library

Sister-chromatid cohesion and genome architecture; general cellular function with no direct post-drug-syndrome link established.

Written for the whole chromosome cohesion family, not for STAG1 specifically.

Mentioned in 0 corpus records

No corpus record names STAG1 directly yet. It is in the library because it sits in a pathway the corpus tracks (Chromosome cohesion).

Also in chromosome cohesion and architecture

All 6 genes

Browse by family on the gene families page.

Gene summary

Source: NCBI Gene, accessed 2026-10-10; corrected that day, as the page had carried PMEPA1's record.

Protein reference (UniProt)

Protein: Cohesin subunit SA-1
Function: Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis.
Subcellular location: Nucleus; Chromosome; Chromosome, centromere.
Associated conditions: Intellectual developmental disorder, autosomal dominant 47 (MRD47).