Pathway candidateNCBI-verifiedprotein-coding

SMC1A

structural maintenance of chromosomes 1A

NCBI Gene: 8243 Ensembl GeneCards UniProt: Q14683

Pathway candidate — not linked to PFS or PSSD by any record here

SMC1A is in the library because it belongs to the chromosome cohesion family. No study, report or commentary in the corpus names it, so a variant in SMC1A is not, by itself, evidence of anything related to post-drug syndromes.

Gene summary

A protein-coding gene on chromosome X (chromosome cohesion and architecture). Proper cohesion of sister chromatids is a prerequisite for the correct segregation of chromosomes during cell division. The cohesin multiprotein complex is required for sister chromatid cohesion.

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: Structural maintenance of chromosomes protein 1A
Function: Involved in chromosome cohesion during cell cycle and in DNA repair. Central component of cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. Involved in DNA repair via its interaction with BRCA1 and its related phosphorylation by ATM, or via its phosphorylation by ATR. Works as a downstream effector both in the ATM/NBS1 branch and in the ATR/MSH2 branch of S-phase checkpoint.
Subcellular location: Nucleus; Chromosome; Chromosome, centromere, kinetochore.
Associated conditions: Cornelia de Lange syndrome 2 (CDLS2); Developmental and epileptic encephalopathy 85 with or without midline brain defects (DEE85).

Source: UniProtKB/Swiss-Prot Q14683, release 2026_03, licensed CC BY 4.0. This is the protein’s normal biology, not evidence about post-drug syndromes; associated conditions are inherited disorders of the gene, not PFS, PSSD or PRSD.

Why its pathway is in the library

Sister-chromatid cohesion and genome architecture; general cellular function with no direct post-drug-syndrome link established.

Written for the whole chromosome cohesion family, not for SMC1A specifically.

Mentioned in 0 corpus records

No corpus record names SMC1A directly yet. It is in the library because it sits in a pathway the corpus tracks (Chromosome cohesion).

Also in chromosome cohesion and architecture

All 6 genes

Browse by family on the gene families page.

Gene summary

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: Structural maintenance of chromosomes protein 1A
Function: Involved in chromosome cohesion during cell cycle and in DNA repair. Central component of cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. Involved in DNA repair via its interaction with BRCA1 and its related phosphorylation by ATM, or via its phosphorylation by ATR. Works as a downstream effector both in the ATM/NBS1 branch and in the ATR/MSH2 branch of S-phase checkpoint.
Subcellular location: Nucleus; Chromosome; Chromosome, centromere, kinetochore.
Associated conditions: Cornelia de Lange syndrome 2 (CDLS2); Developmental and epileptic encephalopathy 85 with or without midline brain defects (DEE85).