Pathway candidateNCBI-verifiedprotein-coding

RORA

RAR related orphan receptor A

NCBI Gene: 6095 Ensembl GeneCards UniProt: P35398

Pathway candidate — not linked to PFS or PSSD by any record here

RORA is in the library because it belongs to the nuclear receptors family. No study, report or commentary in the corpus names it, so a variant in RORA is not, by itself, evidence of anything related to post-drug syndromes.

Gene summary

A protein-coding gene on chromosome 15 (steroid and nuclear hormone receptors). The protein encoded by this gene is a member of the NR1 subfamily of nuclear hormone receptors. It can bind as a monomer or as a homodimer to hormone response elements upstream of several genes to enhance the expression of those genes.

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: Nuclear receptor ROR-alpha
Function (excerpt): Nuclear receptor that binds DNA as a monomer to ROR response elements (RORE) containing a single core motif half-site 5'-AGGTCA-3' preceded by a short A-T-rich sequence. Key regulator of embryonic development, cellular differentiation, immunity, circadian rhythm as well as lipid, steroid, xenobiotics and glucose metabolism. Considered to have intrinsic transcriptional activity, have some natural ligands like oxysterols that act as agonists (25-hydroxycholesterol) or inverse agonists (7-oxygenated sterols), enhancing or repressing the transcriptional activity, respectively. Recruits distinct combinations of cofactors to target genes regulatory regions to modulate their transcriptional expression, depending on the tissue, time and promoter contexts. Regulates genes involved in photoreceptor development including OPN1SW, OPN1SM and ARR3 and skeletal muscle development with MYOD1. Required for proper cerebellum development.
Subcellular location: Nucleus.
Tissue specificity: Widely expressed in a number of tissues. Expressed in both regulatory T-cells (Treg) and effector T-cells (Teff). Isoform 4: Highly expressed in the central nervous system, including in the cerebellum.
Associated conditions: Intellectual developmental disorder with or without epilepsy or cerebellar ataxia (IDDECA).

Source: UniProtKB/Swiss-Prot P35398, release 2026_03, licensed CC BY 4.0. This is the protein’s normal biology, not evidence about post-drug syndromes; associated conditions are inherited disorders of the gene, not PFS, PSSD or PRSD.

Why its pathway is in the library

Nuclear receptors transduce steroid signals into lasting gene-expression programs; persistent receptor-level remodeling (or silencing) is a leading hypothesis for symptoms that outlast drug exposure.

Written for the whole nuclear receptors family, not for RORA specifically.

Mentioned in 0 corpus records

No corpus record names RORA directly yet. It is in the library because it sits in a pathway the corpus tracks (Nuclear receptors).

Also in steroid and nuclear hormone receptors

All 41 genes

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Gene summary

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: Nuclear receptor ROR-alpha
Function (excerpt): Nuclear receptor that binds DNA as a monomer to ROR response elements (RORE) containing a single core motif half-site 5'-AGGTCA-3' preceded by a short A-T-rich sequence. Key regulator of embryonic development, cellular differentiation, immunity, circadian rhythm as well as lipid, steroid, xenobiotics and glucose metabolism. Considered to have intrinsic transcriptional activity, have some natural ligands like oxysterols that act as agonists (25-hydroxycholesterol) or inverse agonists (7-oxygenated sterols), enhancing or repressing the transcriptional activity, respectively. Recruits distinct combinations of cofactors to target genes regulatory regions to modulate their transcriptional expression, depending on the tissue, time and promoter contexts. Regulates genes involved in photoreceptor development including OPN1SW, OPN1SM and ARR3 and skeletal muscle development with MYOD1. Required for proper cerebellum development.
Subcellular location: Nucleus.
Tissue specificity: Widely expressed in a number of tissues. Expressed in both regulatory T-cells (Treg) and effector T-cells (Teff). Isoform 4: Highly expressed in the central nervous system, including in the cerebellum.
Associated conditions: Intellectual developmental disorder with or without epilepsy or cerebellar ataxia (IDDECA).