Pathway candidateNCBI-verifiedprotein-coding

TAC3

tachykinin precursor 3

NCBI Gene: 6866 Ensembl GeneCards UniProt: Q9UHF0

Pathway candidate — not linked to PFS or PSSD by any record here

TAC3 is in the library because it belongs to the hpg / gonadal axis family. No study, report or commentary in the corpus names it, so a variant in TAC3 is not, by itself, evidence of anything related to post-drug syndromes.

Gene summary

A protein-coding gene on chromosome 12 (hpg and gonadal axis). Encodes a member of the tachykinin family of secreted neuropeptides. The encoded preproprotein is proteolytically processed to generate the mature peptide, which is primarily expressed in the central and peripheral nervous systems and functions as a neurotransmitter.

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: Tachykinin-3
Function: Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles.
Subcellular location: Secreted.
Associated conditions: Hypogonadotropic hypogonadism 10 with or without anosmia (HH10).

Source: UniProtKB/Swiss-Prot Q9UHF0, release 2026_03, licensed CC BY 4.0. This is the protein’s normal biology, not evidence about post-drug syndromes; associated conditions are inherited disorders of the gene, not PFS, PSSD or PRSD.

Why its pathway is in the library

HPG-axis signaling and steroid carrier proteins govern testosterone production and bioavailability — central to the endocrine phenotype of post-drug syndromes.

Written for the whole hpg / gonadal axis family, not for TAC3 specifically.

Mentioned in 0 corpus records

No corpus record names TAC3 directly yet. It is in the library because it sits in a pathway the corpus tracks (HPG / gonadal axis).

Also in hpg and gonadal axis

All 11 genes

Browse by family on the gene families page.

Gene summary

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: Tachykinin-3
Function: Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles.
Subcellular location: Secreted.
Associated conditions: Hypogonadotropic hypogonadism 10 with or without anosmia (HH10).