Pathway candidateNCBI-verifiedprotein-coding

TACR3

tachykinin receptor 3

NCBI Gene: 6870 Ensembl GeneCards UniProt: P29371

Pathway candidate — not linked to PFS or PSSD by any record here

TACR3 is in the library because it belongs to the hpg / gonadal axis family. No study, report or commentary in the corpus names it, so a variant in TACR3 is not, by itself, evidence of anything related to post-drug syndromes.

Gene summary

A protein-coding gene on chromosome 4 (hpg and gonadal axis). This gene belongs to a family of genes that function as receptors for tachykinins. Receptor affinities are specified by variations in the 5'-end of the sequence.

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: Neuromedin-K receptor
Function: Receptor for the tachykinin neuromedin-K (neurokinin B), also able to bind and respond to tachynins substance K/neurokinin A and substance P. The rank order of affinity of this receptor to tachykinins is: neuromedin-K > substance K and substance P. Neuromedin-K binding to its receptor triggers G protein-coupled receptor signaling via activation of G(q) and phosphatidylinositol hydrolysis by phospholipase C. Neuromedin-K binding also triggers signaling via activation of adenylate cyclase activity which results in increased intracellular levels of cyclic AMP (cAMP) (By similarity).
Subcellular location: Cell membrane.
Associated conditions: Hypogonadotropic hypogonadism 11 with or without anosmia (HH11).

Source: UniProtKB/Swiss-Prot P29371, release 2026_03, licensed CC BY 4.0. This is the protein’s normal biology, not evidence about post-drug syndromes; associated conditions are inherited disorders of the gene, not PFS, PSSD or PRSD.

Why its pathway is in the library

HPG-axis signaling and steroid carrier proteins govern testosterone production and bioavailability — central to the endocrine phenotype of post-drug syndromes.

Written for the whole hpg / gonadal axis family, not for TACR3 specifically.

Mentioned in 0 corpus records

No corpus record names TACR3 directly yet. It is in the library because it sits in a pathway the corpus tracks (HPG / gonadal axis).

Also in hpg and gonadal axis

All 11 genes

Browse by family on the gene families page.

Protein reference (UniProt)

Protein: Neuromedin-K receptor
Function: Receptor for the tachykinin neuromedin-K (neurokinin B), also able to bind and respond to tachynins substance K/neurokinin A and substance P. The rank order of affinity of this receptor to tachykinins is: neuromedin-K > substance K and substance P. Neuromedin-K binding to its receptor triggers G protein-coupled receptor signaling via activation of G(q) and phosphatidylinositol hydrolysis by phospholipase C. Neuromedin-K binding also triggers signaling via activation of adenylate cyclase activity which results in increased intracellular levels of cyclic AMP (cAMP) (By similarity).
Subcellular location: Cell membrane.
Associated conditions: Hypogonadotropic hypogonadism 11 with or without anosmia (HH11).