Pathway candidateNCBI-verifiedprotein-coding

TARBP2

TARBP2 subunit of RISC loading complex

NCBI Gene: 6895 Ensembl GeneCards UniProt: Q15633

Pathway candidate — not linked to PFS or PSSD by any record here

TARBP2 is in the library because it belongs to the rna processing family. No study, report or commentary in the corpus names it, so a variant in TARBP2 is not, by itself, evidence of anything related to post-drug syndromes.

Gene summary

A protein-coding gene on chromosome 12 (rna processing and mirna biogenesis). HIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome that produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the transactivator Tat is dependent on an RNA regulatory element (TAR) located downstream of the transcription initiation site.

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: RISC-loading complex subunit TARBP2
Function: Required for formation of the RNA induced silencing complex (RISC). Component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, AGO2 and TARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto AGO2. AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2. May also play a role in the production of short interfering RNAs (siRNAs) from double-stranded RNA (dsRNA) by DICER1 (By similarity). Binds in vitro to the PRM1 3'-UTR (By similarity). Seems to act as a repressor of translation (By similarity). For some pre-miRNA substrates, may also alter the choice of cleavage site by DICER1. Negatively regulates IRF7-mediated IFN-beta signaling triggered by viral infection by inhibiting the phosphorylation of IRF7 and promoting its 'Lys'-48-linked ubiquitination and degradation.
Subcellular location: Cytoplasm; Cytoplasm, perinuclear region; Nucleus.

Source: UniProtKB/Swiss-Prot Q15633, release 2026_03, licensed CC BY 4.0. This is the protein’s normal biology, not evidence about post-drug syndromes; associated conditions are inherited disorders of the gene, not PFS, PSSD or PRSD.

Why its pathway is in the library

miRNA biogenesis and RNA handling; epigenetic-adjacent regulation with no direct post-drug-syndrome link established.

Written for the whole rna processing family, not for TARBP2 specifically.

Mentioned in 0 corpus records

No corpus record names TARBP2 directly yet. It is in the library because it sits in a pathway the corpus tracks (RNA processing).

Also in rna processing and mirna biogenesis

All 11 genes

Browse by family on the gene families page.

Gene summary

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: RISC-loading complex subunit TARBP2
Function: Required for formation of the RNA induced silencing complex (RISC). Component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, AGO2 and TARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto AGO2. AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2. May also play a role in the production of short interfering RNAs (siRNAs) from double-stranded RNA (dsRNA) by DICER1 (By similarity). Binds in vitro to the PRM1 3'-UTR (By similarity). Seems to act as a repressor of translation (By similarity). For some pre-miRNA substrates, may also alter the choice of cleavage site by DICER1. Negatively regulates IRF7-mediated IFN-beta signaling triggered by viral infection by inhibiting the phosphorylation of IRF7 and promoting its 'Lys'-48-linked ubiquitination and degradation.
Subcellular location: Cytoplasm; Cytoplasm, perinuclear region; Nucleus.