Pathway candidateNCBI-verifiedprotein-coding

THRB

thyroid hormone receptor beta

NCBI Gene: 7068 Ensembl GeneCards UniProt: P10828

Pathway candidate — not linked to PFS or PSSD by any record here

THRB is in the library because it belongs to the nuclear receptors family. No study, report or commentary in the corpus names it, so a variant in THRB is not, by itself, evidence of anything related to post-drug syndromes.

Gene summary

A protein-coding gene on chromosome 3 (steroid and nuclear hormone receptors). The protein encoded by this gene is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone.

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: Thyroid hormone receptor beta
Function: Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine.
Subcellular location: Nucleus.
Associated conditions: Thyroid hormone resistance, generalized, autosomal dominant (GRTHD); Thyroid hormone resistance, generalized, autosomal recessive (GRTHR); Selective pituitary thyroid hormone resistance (PRTH).

Source: UniProtKB/Swiss-Prot P10828, release 2026_03, licensed CC BY 4.0. This is the protein’s normal biology, not evidence about post-drug syndromes; associated conditions are inherited disorders of the gene, not PFS, PSSD or PRSD.

Why its pathway is in the library

Nuclear receptors transduce steroid signals into lasting gene-expression programs; persistent receptor-level remodeling (or silencing) is a leading hypothesis for symptoms that outlast drug exposure.

Written for the whole nuclear receptors family, not for THRB specifically.

Mentioned in 0 corpus records

No corpus record names THRB directly yet. It is in the library because it sits in a pathway the corpus tracks (Nuclear receptors).

Also in steroid and nuclear hormone receptors

All 41 genes

Browse by family on the gene families page.

Gene summary

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: Thyroid hormone receptor beta
Function: Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine.
Subcellular location: Nucleus.
Associated conditions: Thyroid hormone resistance, generalized, autosomal dominant (GRTHD); Thyroid hormone resistance, generalized, autosomal recessive (GRTHR); Selective pituitary thyroid hormone resistance (PRTH).