Pathway candidate — not linked to PFS or PSSD by any record here
Gene summary
A protein-coding gene on chromosome 12 (steroid and nuclear hormone receptors). Encodes vitamin D3 receptor, which is a member of the nuclear hormone receptor superfamily of ligand-inducible transcription factors. This receptor also functions as a receptor for the secondary bile acid, lithocholic acid.
Source: NCBI Gene, accessed 2026-10-07.
Protein reference (UniProt)
- Protein
Vitamin D3 receptor
- Function
Nuclear receptor for calcitriol, the active form of vitamin D3 which mediates the action of this vitamin on cells. Enters the nucleus upon vitamin D3 binding where it forms heterodimers with the retinoid X receptor/RXR. The VDR-RXR heterodimers bind to specific response elements on DNA and activate the transcription of vitamin D3-responsive target genes. Plays a central role in calcium homeostasis (By similarity). Also functions as a receptor for the secondary bile acid lithocholic acid (LCA) and its metabolites.
- Subcellular location
Nucleus; Cytoplasm.
- Associated conditions
Rickets vitamin D-dependent 2A (VDDR2A).
Source: UniProtKB/Swiss-Prot P11473, release 2026_03, licensed CC BY 4.0. This is the protein’s normal biology, not evidence about post-drug syndromes; associated conditions are inherited disorders of the gene, not PFS, PSSD or PRSD.
Why its pathway is in the library
Nuclear receptors transduce steroid signals into lasting gene-expression programs; persistent receptor-level remodeling (or silencing) is a leading hypothesis for symptoms that outlast drug exposure.
Written for the whole nuclear receptors family, not for VDR specifically.
Mentioned in 0 corpus records
No corpus record names VDR directly yet. It is in the library because it sits in a pathway the corpus tracks (Nuclear receptors).
Also in steroid and nuclear hormone receptors
All 41 genes- ARPowers
androgen receptor
chr X· Nuclear receptors· 41 records - ESR1
estrogen receptor 1
chr 6· Nuclear receptors· 1 record - ESR2
estrogen receptor 2
chr 14· Nuclear receptors· Pathway candidate - FOXA1
forkhead box A1
chr 14· Nuclear receptors· Pathway candidate - HNF4A
hepatocyte nuclear factor 4 alpha
chr 20· Nuclear receptors· Pathway candidate - HNF4G
hepatocyte nuclear factor 4 gamma
chr 8· Nuclear receptors· Pathway candidate - NCOA1
nuclear receptor coactivator 1
chr 2· Nuclear receptors· Pathway candidate - NCOA2
nuclear receptor coactivator 2
chr 8· Nuclear receptors· Pathway candidate
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