Indomethacin-associated sexual dysfunction
L G Miller, J C Rogers, D E Swee
Journal of Family Practice1989
Summary (paraphrased)
A brief 1989 case report from Baylor College of Medicine's Department of Family Medicine describing a case of sexual dysfunction associated with indomethacin, an NSAID prescribed for back pain. The PubMed record lists no abstract; the MeSH indexing classifies it as chemically induced erectile dysfunction in a middle-aged male (Case Reports). NOTE: the Discord list labeled this link 'Aryl-sulfatase activity' — that label is wrong; PMID 2526860 is this indomethacin case report.
Why it’s in the corpus
Directly relevant as an early example of drug-induced sexual dysfunction being reported in the literature — the same phenomenon class that PFS/PSSD describe, here with an NSAID rather than finasteride or an SSRI, supporting the corpus's 'related post-drug syndromes' scope.
Related records
- Peer-reviewed paperPSSD Discord pick
Cutting edge: agonistic effect of indomethacin on a prostaglandin D2 receptor, CRTH2
Hiroyuki Hirai, Kazuya Tanaka, Shoichi Takano, Michiko Ichimasa, Masataka Nakamura, Kinya Nagata · The Journal of Immunology
Found that indomethacin — normally known as a COX inhibitor — acts as a functional agonist of the PGD2 receptor CRTH2 (now DP2) at submicromolar concentrations, driving calcium mobilization and chemotaxis of Th2 cells, eosinophils, and basophils, while other…
DISC-0182002PFSPSSDPSSD Discord picks