Post-SSRI Sexual Dysfunction (PSSD): Ten Year Retrospective Chart Review

From a decade of charts at a sexual-medicine practice, the authors identified 43 young men (mean age 31) meeting PSSD criteria — about 4% of male patients seen — with erectile dysfunction the most common complaint (93%) and a mean erectile-function score in the severe range. Workup included validated questionnaires, Doppler ultrasound during pharmacological erection, and quantitative sensory testing of vibration, warmth, and cold perception. The study provides rare objective clinical data on PSSD, including sensory testing results consistent with a peripheral sensory component.