Towards Improving Post-SSRI Sexual Dysfunction by Using Nutriceuticals: Lessons from a Case Study
Rocco Salvatore Calabrò; Rosaria De Luca; Alfredo Manuli; Simona Portaro; Antonino Naro; Fabrizio Quattrini
Journal of Sex & Marital Therapy2019
Summary (paraphrased)
The authors describe a PSSD patient — persistent genital hypoesthesia, loss of libido, and erectile dysfunction after SSRI discontinuation — treated with a nutraceutical regimen, and report improvement in sexual function. They review the sparse treatment literature and propose that nutritional/pharmacological strategies targeting neurotransmitter and hormonal balance deserve systematic investigation. The paper frames PSSD as a distinct clinical entity whose lack of proven therapies forces clinicians toward experimental approaches.
Why it’s in the corpus
One of very few published treatment attempts for PSSD. Documents the therapeutic vacuum and an early experimental strategy.
Related records
- Peer-reviewed paper
The pathophysiology of Post SSRI Sexual Dysfunction – Lessons from a case study
Samantha Klaas; Jessica Barbut Siva; Maarten Bak; Mark Govers; Rudy Schreiber · Biomedicine & Pharmacotherapy
The authors present a detailed PSSD case and use it to walk through candidate biological mechanisms for the syndrome, noting that although regulators now recognize PSSD, it remains poorly understood, underdiagnosed, and undertreated. The discussion surveys…
LIT-0272023PSSDLiterature sweep · Oct 2026 - Peer-reviewed paper
Cutting the First Turf to Heal Post-SSRI Sexual Dysfunction: A Male Retrospective Cohort Study
Rosaria De Luca; Mirjam Bonanno; Alfredo Manuli; Rocco Salvatore Calabrò · Medicines
Thirteen men with PSSD after citalopram, paroxetine, sertraline, fluoxetine, or escitalopram were followed retrospectively after receiving varied individualized treatments, most commonly vortioxetine (alone in five men, with turmeric or nutraceuticals in one…
LIT-0292022PSSDLiterature sweep · Oct 2026 - Peer-reviewed paper
Psychological and sexual functioning of persons suffering from post-SSRI sexual dysfunction – cases study
Kacper Gargul; Beata Pastwa-Wojciechowska · Current Issues in Personality Psychology
While most PSSD research has catalogued somatic symptoms, this case study focuses on the psychological side: the authors described the sexual functioning, and feelings about it, of four young women aged 22-27 before, during and after SSRI treatment, using a…
LIT-0342025PSSDLiterature sweep · Oct 2026
