Pathway candidateNCBI-verifiedprotein-coding

AVPR2

arginine vasopressin receptor 2

NCBI Gene: 554 Ensembl GeneCards UniProt: P30518

Pathway candidate — not linked to PFS or PSSD by any record here

AVPR2 is in the library because it belongs to the neuroendocrine signaling family. No study, report or commentary in the corpus names it, so a variant in AVPR2 is not, by itself, evidence of anything related to post-drug syndromes.

Gene summary

A protein-coding gene on chromosome X (neuroendocrine and peptide signaling). Encodes the vasopressin receptor, type 2, also known as the V2 receptor, which belongs to the seven-transmembrane-domain G protein-coupled receptor (GPCR) superfamily, and couples to Gs thus stimulating adenylate cyclase. The subfamily that includes the V2 receptor, the V1a and V1b vasopressin receptors, the oxytocin receptor, and isotocin and mesotocin receptors in non-mammals, is well conserved, though several members signal via other G proteins.

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: Vasopressin V2 receptor
Function: G protein-coupled receptor for arginine vasopressin, an antidiuretic that promotes renal water reabsorption. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase (cAMP). AVPR2 is coupled to G(s) G alpha proteins and mediates activation of adenylate cyclase activity.
Subcellular location: Cell membrane.
Tissue specificity: Kidney.
Associated conditions: Nephrogenic syndrome of inappropriate antidiuresis (NSIAD); Diabetes insipidus, nephrogenic, 1, X-linked (NDI1).

Source: UniProtKB/Swiss-Prot P30518, release 2026_03, licensed CC BY 4.0. This is the protein’s normal biology, not evidence about post-drug syndromes; associated conditions are inherited disorders of the gene, not PFS, PSSD or PRSD.

Why its pathway is in the library

Peptide-hormone and related signaling modulates sexual function, stress, and behavior — symptom domains prominent in PSSD/PFS.

Written for the whole neuroendocrine signaling family, not for AVPR2 specifically.

Mentioned in 0 corpus records

No corpus record names AVPR2 directly yet. It is in the library because it sits in a pathway the corpus tracks (Neuroendocrine signaling).

Also in neuroendocrine and peptide signaling

All 12 genes

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Gene summary

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: Vasopressin V2 receptor
Function: G protein-coupled receptor for arginine vasopressin, an antidiuretic that promotes renal water reabsorption. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase (cAMP). AVPR2 is coupled to G(s) G alpha proteins and mediates activation of adenylate cyclase activity.
Subcellular location: Cell membrane.
Tissue specificity: Kidney.
Associated conditions: Nephrogenic syndrome of inappropriate antidiuresis (NSIAD); Diabetes insipidus, nephrogenic, 1, X-linked (NDI1).