GNB3
G protein subunit beta 3
Gene summary
A protein-coding gene on chromosome 12 (neuroendocrine and peptide signaling). Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes.
Source: NCBI Gene, accessed 2026-10-07.
Protein reference (UniProt)
- Protein
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3
- Function
Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.
- Associated conditions
Night blindness, congenital stationary, 1H (CSNB1H).
Source: UniProtKB/Swiss-Prot P16520, release 2026_03, licensed CC BY 4.0. This is the protein’s normal biology, not evidence about post-drug syndromes; associated conditions are inherited disorders of the gene, not PFS, PSSD or PRSD.
Why its pathway is in the library
Peptide-hormone and related signaling modulates sexual function, stress, and behavior — symptom domains prominent in PSSD/PFS.
Written for the whole neuroendocrine signaling family, not for GNB3 specifically.
Mentioned in 1 corpus record
- Peer-reviewed paper
Serotonin 2A -1438 G/A and G-Protein Beta3 Subunit C825T Polymorphisms in Patients with Depression and SSRI-Associated Sexual Side-Effects
Jeffrey R. Bishop, Jessica Moline, Vicki L. Ellingrod, Susan K. Schultz, Anita H. Clayton · Neuropsychopharmacology
In 81 outpatients treated with citalopram, escitalopram, fluoxetine, paroxetine, or sertraline, sexual dysfunction was measured with the Changes in Sexual Function Questionnaire as a primary outcome. The HTR2A -1438 G/G genotype was associated with…
GNB3HTR2AMECH-0372006PSSDSystems review · Oct 2026
Also in neuroendocrine and peptide signaling
All 12 genes- AVPR1A
arginine vasopressin receptor 1A
chr 12· Neuroendocrine signaling· Pathway candidate - AVPR1B
arginine vasopressin receptor 1B
chr 1· Neuroendocrine signaling· Pathway candidate - AVPR2
arginine vasopressin receptor 2
chr X· Neuroendocrine signaling· Pathway candidate - MC4R
melanocortin 4 receptor
chr 18· Neuroendocrine signaling· Pathway candidate - NOS1
nitric oxide synthase 1
chr 12· Neuroendocrine signaling· Pathway candidate - NOS3
nitric oxide synthase 3
chr 7· Neuroendocrine signaling· Pathway candidate - NPY
neuropeptide Y
chr 7· Neuroendocrine signaling· Pathway candidate - NPY1R
neuropeptide Y receptor Y1
chr 4· Neuroendocrine signaling· Pathway candidate
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