Pathway candidateNCBI-verifiedprotein-coding

NPY

neuropeptide Y

NCBI Gene: 4852 Ensembl GeneCards UniProt: P01303

Pathway candidate — not linked to PFS or PSSD by any record here

NPY is in the library because it belongs to the neuroendocrine signaling family. No study, report or commentary in the corpus names it, so a variant in NPY is not, by itself, evidence of anything related to post-drug syndromes.

Gene summary

A protein-coding gene on chromosome 7 (neuroendocrine and peptide signaling). Encodes a neuropeptide that is widely expressed in the central nervous system and influences many physiological processes, including cortical excitability, stress response, food intake, circadian rhythms, and cardiovascular function. The neuropeptide functions through G protein-coupled receptors to inhibit adenylyl cyclase, activate mitogen-activated protein kinase (MAPK), regulate intracellular calcium levels, and activate potassium channels.

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: Pro-neuropeptide Y
Function: Neuropeptide Y: Ligand for neuropeptide Y receptor type 1 (NPY1R) and neuropeptide Y receptor type 2 (NPY2R). Receptor binding induces adenylate cyclase-inhibiting G protein-coupled receptor signaling, resulting in inhibition of cAMP production. Receptor activation by NPY also leads to an increase of intracellular Ca(2+) levels. Is involved in the regulation of eating behavior, acting as a stimulator of food intake (By similarity). Involved in the regulation of colonic antisecretory tone, and colonic contractility (By similarity).
Subcellular location: Secreted; Cytoplasmic vesicle, secretory vesicle, neuronal dense core vesicle.
Tissue specificity: One of the most abundant peptides in the nervous system. Also found in some chromaffin cells of the adrenal medulla.

Source: UniProtKB/Swiss-Prot P01303, release 2026_03, licensed CC BY 4.0. This is the protein’s normal biology, not evidence about post-drug syndromes; associated conditions are inherited disorders of the gene, not PFS, PSSD or PRSD.

Why its pathway is in the library

Peptide-hormone and related signaling modulates sexual function, stress, and behavior — symptom domains prominent in PSSD/PFS.

Written for the whole neuroendocrine signaling family, not for NPY specifically.

Mentioned in 0 corpus records

No corpus record names NPY directly yet. It is in the library because it sits in a pathway the corpus tracks (Neuroendocrine signaling).

Also in neuroendocrine and peptide signaling

All 12 genes

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Gene summary

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: Pro-neuropeptide Y
Function: Neuropeptide Y: Ligand for neuropeptide Y receptor type 1 (NPY1R) and neuropeptide Y receptor type 2 (NPY2R). Receptor binding induces adenylate cyclase-inhibiting G protein-coupled receptor signaling, resulting in inhibition of cAMP production. Receptor activation by NPY also leads to an increase of intracellular Ca(2+) levels. Is involved in the regulation of eating behavior, acting as a stimulator of food intake (By similarity). Involved in the regulation of colonic antisecretory tone, and colonic contractility (By similarity).
Subcellular location: Secreted; Cytoplasmic vesicle, secretory vesicle, neuronal dense core vesicle.
Tissue specificity: One of the most abundant peptides in the nervous system. Also found in some chromaffin cells of the adrenal medulla.