Pathway candidateNCBI-verifiedprotein-coding

NOS1

nitric oxide synthase 1

NCBI Gene: 4842 Ensembl GeneCards UniProt: P29475

Pathway candidate — not linked to PFS or PSSD by any record here

NOS1 is in the library because it belongs to the neuroendocrine signaling family. No study, report or commentary in the corpus names it, so a variant in NOS1 is not, by itself, evidence of anything related to post-drug syndromes.

Gene summary

A protein-coding gene on chromosome 12 (neuroendocrine and peptide signaling). The protein encoded by this gene belongs to the family of nitric oxide synthases, which synthesize nitric oxide from L-arginine. Nitric oxide is a reactive free radical, which acts as a biologic mediator in several processes, including neurotransmission, and antimicrobial and antitumoral activities.

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: Nitric oxide synthase 1
Function: Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In the brain and peripheral nervous system, NO displays many properties of a neurotransmitter. Probably has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such SRR.
Subcellular location: Cell membrane, sarcolemma; Cell projection, dendritic spine.
Tissue specificity: Isoform 1 is ubiquitously expressed: detected in skeletal muscle and brain, also in testis, lung and kidney, and at low levels in heart, adrenal gland and retina. Not detected in the platelets. Isoform 3 is expressed only in testis. Isoform 4 is detected in testis, skeletal muscle, lung, and kidney, at low levels in the brain, but not in the heart and adrenal gland.

Source: UniProtKB/Swiss-Prot P29475, release 2026_03, licensed CC BY 4.0. This is the protein’s normal biology, not evidence about post-drug syndromes; associated conditions are inherited disorders of the gene, not PFS, PSSD or PRSD.

Why its pathway is in the library

Peptide-hormone and related signaling modulates sexual function, stress, and behavior — symptom domains prominent in PSSD/PFS.

Written for the whole neuroendocrine signaling family, not for NOS1 specifically.

Mentioned in 0 corpus records

No corpus record names NOS1 directly yet. It is in the library because it sits in a pathway the corpus tracks (Neuroendocrine signaling).

Also in neuroendocrine and peptide signaling

All 12 genes

Browse by family on the gene families page.

Gene summary

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: Nitric oxide synthase 1
Function: Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In the brain and peripheral nervous system, NO displays many properties of a neurotransmitter. Probably has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such SRR.
Subcellular location: Cell membrane, sarcolemma; Cell projection, dendritic spine.
Tissue specificity: Isoform 1 is ubiquitously expressed: detected in skeletal muscle and brain, also in testis, lung and kidney, and at low levels in heart, adrenal gland and retina. Not detected in the platelets. Isoform 3 is expressed only in testis. Isoform 4 is detected in testis, skeletal muscle, lung, and kidney, at low levels in the brain, but not in the heart and adrenal gland.