NOS3
nitric oxide synthase 3
Pathway candidate — not linked to PFS or PSSD by any record here
Gene summary
A protein-coding gene on chromosome 7 (neuroendocrine and peptide signaling). Nitric oxide is a reactive free radical which acts as a biologic mediator in several processes, including neurotransmission and antimicrobial and antitumoral activities. Nitric oxide is synthesized from L-arginine by nitric oxide synthases.
Source: NCBI Gene, accessed 2026-10-07.
Protein reference (UniProt)
- Protein
Nitric oxide synthase 3
- Function
Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets.
- Subcellular location
Cell membrane; Membrane, caveola; Cytoplasm, cytoskeleton; Golgi apparatus.
- Tissue specificity
Platelets, placenta, liver and kidney.
- Associated conditions
Moyamoya disease 8 (MYMY8).
Source: UniProtKB/Swiss-Prot P29474, release 2026_03, licensed CC BY 4.0. This is the protein’s normal biology, not evidence about post-drug syndromes; associated conditions are inherited disorders of the gene, not PFS, PSSD or PRSD.
Why its pathway is in the library
Peptide-hormone and related signaling modulates sexual function, stress, and behavior — symptom domains prominent in PSSD/PFS.
Written for the whole neuroendocrine signaling family, not for NOS3 specifically.
Mentioned in 0 corpus records
No corpus record names NOS3 directly yet. It is in the library because it sits in a pathway the corpus tracks (Neuroendocrine signaling).
Also in neuroendocrine and peptide signaling
All 12 genes- GNB3
G protein subunit beta 3
chr 12· Neuroendocrine signaling· 1 record - AVPR1A
arginine vasopressin receptor 1A
chr 12· Neuroendocrine signaling· Pathway candidate - AVPR1B
arginine vasopressin receptor 1B
chr 1· Neuroendocrine signaling· Pathway candidate - AVPR2
arginine vasopressin receptor 2
chr X· Neuroendocrine signaling· Pathway candidate - MC4R
melanocortin 4 receptor
chr 18· Neuroendocrine signaling· Pathway candidate - NOS1
nitric oxide synthase 1
chr 12· Neuroendocrine signaling· Pathway candidate - NPY
neuropeptide Y
chr 7· Neuroendocrine signaling· Pathway candidate - NPY1R
neuropeptide Y receptor Y1
chr 4· Neuroendocrine signaling· Pathway candidate
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