Pathway candidateNCBI-verifiedprotein-coding

NPY1R

neuropeptide Y receptor Y1

NCBI Gene: 4886 Ensembl GeneCards UniProt: P25929

Pathway candidate — not linked to PFS or PSSD by any record here

NPY1R is in the library because it belongs to the neuroendocrine signaling family. No study, report or commentary in the corpus names it, so a variant in NPY1R is not, by itself, evidence of anything related to post-drug syndromes.

Gene summary

A protein-coding gene on chromosome 4 (neuroendocrine and peptide signaling). This gene belongs to the G-protein-coupled receptor superfamily. The encoded transmembrane protein mediates the function of neuropeptide Y (NPY), a neurotransmitter, and peptide YY (PYY), a gastrointestinal hormone.

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: Neuropeptide Y receptor type 1
Function: Receptor for neuropeptide Y (NPY) and peptide YY (PYY). Can also bind with high affinity [Leu-31, Pro-34]NPY, an analog of NPY modified at residues 31 and 34 of the mature form, while having virtually no affinity for pancreatic polypeptide (PP/PPY) at physiological concentrations. NPY or PYY binding induces adenylate cyclase-inhibiting G protein-coupled receptor signaling, resulting in inhibition of cAMP production. Receptor activation by ligands also leads to an increase of intracellular Ca(2+) levels. As a receptor for NPY, it is involved in the regulation of eating behavior and NPY-induced stimulation of food intake (By similarity). Involved in the regulation of colonic antisecretory tone, and colonic contractility (By similarity).
Subcellular location: Cell membrane.

Source: UniProtKB/Swiss-Prot P25929, release 2026_03, licensed CC BY 4.0. This is the protein’s normal biology, not evidence about post-drug syndromes; associated conditions are inherited disorders of the gene, not PFS, PSSD or PRSD.

Why its pathway is in the library

Peptide-hormone and related signaling modulates sexual function, stress, and behavior — symptom domains prominent in PSSD/PFS.

Written for the whole neuroendocrine signaling family, not for NPY1R specifically.

Mentioned in 0 corpus records

No corpus record names NPY1R directly yet. It is in the library because it sits in a pathway the corpus tracks (Neuroendocrine signaling).

Also in neuroendocrine and peptide signaling

All 12 genes

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Gene summary

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: Neuropeptide Y receptor type 1
Function: Receptor for neuropeptide Y (NPY) and peptide YY (PYY). Can also bind with high affinity [Leu-31, Pro-34]NPY, an analog of NPY modified at residues 31 and 34 of the mature form, while having virtually no affinity for pancreatic polypeptide (PP/PPY) at physiological concentrations. NPY or PYY binding induces adenylate cyclase-inhibiting G protein-coupled receptor signaling, resulting in inhibition of cAMP production. Receptor activation by ligands also leads to an increase of intracellular Ca(2+) levels. As a receptor for NPY, it is involved in the regulation of eating behavior and NPY-induced stimulation of food intake (By similarity). Involved in the regulation of colonic antisecretory tone, and colonic contractility (By similarity).
Subcellular location: Cell membrane.