Pathway candidateNCBI-verifiedprotein-coding

OXTR

oxytocin receptor

NCBI Gene: 5021 Ensembl GeneCards UniProt: P30559

Pathway candidate — not linked to PFS or PSSD by any record here

OXTR is in the library because it belongs to the neuroendocrine signaling family. No study, report or commentary in the corpus names it, so a variant in OXTR is not, by itself, evidence of anything related to post-drug syndromes.

Gene summary

A protein-coding gene on chromosome 3 (neuroendocrine and peptide signaling). The protein encoded by this gene belongs to the G-protein coupled receptor family and acts as a receptor for oxytocin. Its activity is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system.

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: Oxytocin receptor
Function (excerpt): G protein-coupled receptor for oxytocin (OXT), a neuropeptide hormone released by the posterior pituitary gland that plays a key role in social behavior and other biological processes, such as milk ejection. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as phospholipase C. OXTR is mainly coupled to G(q) G proteins and mediates production of diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) second messengers that modulate the activity of phosphatidylinositol 3-kinase and promote the release of Ca(2+) ions from intracellular stores, respectively. In presence of high levels of oxytocin, also coupled to G(i) G proteins, mediating inhibition of adenylate cyclase activity.
Subcellular location: Cell membrane.

Source: UniProtKB/Swiss-Prot P30559, release 2026_03, licensed CC BY 4.0. This is the protein’s normal biology, not evidence about post-drug syndromes; associated conditions are inherited disorders of the gene, not PFS, PSSD or PRSD.

Why its pathway is in the library

Peptide-hormone and related signaling modulates sexual function, stress, and behavior — symptom domains prominent in PSSD/PFS.

Written for the whole neuroendocrine signaling family, not for OXTR specifically.

Mentioned in 0 corpus records

No corpus record names OXTR directly yet. It is in the library because it sits in a pathway the corpus tracks (Neuroendocrine signaling).

Also in neuroendocrine and peptide signaling

All 12 genes

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Gene summary

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: Oxytocin receptor
Function (excerpt): G protein-coupled receptor for oxytocin (OXT), a neuropeptide hormone released by the posterior pituitary gland that plays a key role in social behavior and other biological processes, such as milk ejection. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as phospholipase C. OXTR is mainly coupled to G(q) G proteins and mediates production of diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) second messengers that modulate the activity of phosphatidylinositol 3-kinase and promote the release of Ca(2+) ions from intracellular stores, respectively. In presence of high levels of oxytocin, also coupled to G(i) G proteins, mediating inhibition of adenylate cyclase activity.
Subcellular location: Cell membrane.