PDE5A
phosphodiesterase 5A
Pathway candidate — not linked to PFS or PSSD by any record here
Gene summary
A protein-coding gene on chromosome 4 (neuroendocrine and peptide signaling). Encodes a cGMP-binding, cGMP-specific phosphodiesterase, a member of the cyclic nucleotide phosphodiesterase family. This phosphodiesterase specifically hydrolyzes cGMP to 5'-GMP.
Source: NCBI Gene, accessed 2026-10-07.
Protein reference (UniProt)
- Protein
cGMP-specific 3',5'-cyclic phosphodiesterase
- Function
Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This phosphodiesterase catalyzes the specific hydrolysis of cGMP to 5'-GMP. Specifically regulates nitric-oxide-generated cGMP.
- Pathway
Purine metabolism; 3',5'-cyclic GMP degradation; GMP from 3',5'-cyclic GMP: step 1/1.
- Tissue specificity
Expressed in aortic smooth muscle cells, heart, placenta, skeletal muscle and pancreas and, to a much lesser extent, in brain, liver and lung.
Source: UniProtKB/Swiss-Prot O76074, release 2026_03, licensed CC BY 4.0. This is the protein’s normal biology, not evidence about post-drug syndromes; associated conditions are inherited disorders of the gene, not PFS, PSSD or PRSD.
Why its pathway is in the library
Peptide-hormone and related signaling modulates sexual function, stress, and behavior — symptom domains prominent in PSSD/PFS.
Written for the whole neuroendocrine signaling family, not for PDE5A specifically.
Mentioned in 0 corpus records
No corpus record names PDE5A directly yet. It is in the library because it sits in a pathway the corpus tracks (Neuroendocrine signaling).
Also in neuroendocrine and peptide signaling
All 12 genes- GNB3
G protein subunit beta 3
chr 12· Neuroendocrine signaling· 1 record - AVPR1A
arginine vasopressin receptor 1A
chr 12· Neuroendocrine signaling· Pathway candidate - AVPR1B
arginine vasopressin receptor 1B
chr 1· Neuroendocrine signaling· Pathway candidate - AVPR2
arginine vasopressin receptor 2
chr X· Neuroendocrine signaling· Pathway candidate - MC4R
melanocortin 4 receptor
chr 18· Neuroendocrine signaling· Pathway candidate - NOS1
nitric oxide synthase 1
chr 12· Neuroendocrine signaling· Pathway candidate - NOS3
nitric oxide synthase 3
chr 7· Neuroendocrine signaling· Pathway candidate - NPY
neuropeptide Y
chr 7· Neuroendocrine signaling· Pathway candidate
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