Pathway candidateNCBI-verifiedprotein-coding

RARA

retinoic acid receptor alpha

Chromosome 17Nuclear receptors retinoid signaling

NCBI Gene: 5914 Ensembl GeneCards UniProt: P10276

Pathway candidate — not linked to PFS or PSSD by any record here

RARA is in the library because it belongs to the nuclear receptors / retinoid signaling family. No study, report or commentary in the corpus names it, so a variant in RARA is not, by itself, evidence of anything related to post-drug syndromes.

Gene summary

A protein-coding gene on chromosome 17 (steroid and nuclear hormone receptors). This gene represents a nuclear retinoic acid receptor. The encoded protein, retinoic acid receptor alpha, regulates transcription in a ligand-dependent manner.

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: Retinoic acid receptor alpha
Function (excerpt): Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone deacetylation, chromatin condensation and transcriptional suppression. On ligand binding, the corepressors dissociate from the receptors and associate with the coactivators leading to transcriptional activation. Formation of a complex with histone deacetylases might lead to inhibition of RARE DNA element binding and to transcriptional repression. Transcriptional activation and RARE DNA element binding might be supported by the transcription factor KLF2.
Subcellular location: Nucleus; Cytoplasm.
Tissue specificity: Expressed in monocytes.

Source: UniProtKB/Swiss-Prot P10276, release 2026_03, licensed CC BY 4.0. This is the protein’s normal biology, not evidence about post-drug syndromes; associated conditions are inherited disorders of the gene, not PFS, PSSD or PRSD.

Why its pathway is in the library

Nuclear receptors transduce steroid signals into lasting gene-expression programs; persistent receptor-level remodeling (or silencing) is a leading hypothesis for symptoms that outlast drug exposure.

Written for the whole nuclear receptors / retinoid signaling family, not for RARA specifically.

Mentioned in 0 corpus records

No corpus record names RARA directly yet. It is in the library because it sits in a pathway the corpus tracks (Nuclear receptors, retinoid signaling).

Also in steroid and nuclear hormone receptors

All 41 genes

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Protein reference (UniProt)

Protein: Retinoic acid receptor alpha
Function (excerpt): Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone deacetylation, chromatin condensation and transcriptional suppression. On ligand binding, the corepressors dissociate from the receptors and associate with the coactivators leading to transcriptional activation. Formation of a complex with histone deacetylases might lead to inhibition of RARE DNA element binding and to transcriptional repression. Transcriptional activation and RARE DNA element binding might be supported by the transcription factor KLF2.
Subcellular location: Nucleus; Cytoplasm.
Tissue specificity: Expressed in monocytes.