Pathway candidateNCBI-verifiedprotein-coding

RARB

retinoic acid receptor beta

Chromosome 3Nuclear receptors retinoid signaling

NCBI Gene: 5915 Ensembl GeneCards UniProt: P10826

Pathway candidate — not linked to PFS or PSSD by any record here

RARB is in the library because it belongs to the nuclear receptors / retinoid signaling family. No study, report or commentary in the corpus names it, so a variant in RARB is not, by itself, evidence of anything related to post-drug syndromes.

Gene summary

A protein-coding gene on chromosome 3 (steroid and nuclear hormone receptors). Encodes retinoic acid receptor beta, a member of the thyroid-steroid hormone receptor superfamily of nuclear transcriptional regulators. This receptor localizes to the cytoplasm and to subnuclear compartments.

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: Retinoic acid receptor beta
Function: Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence or presence of hormone ligand, acts mainly as an activator of gene expression due to weak binding to corepressors. The RXRA/RARB heterodimer can act as a repressor on the DR1 element and as an activator on the DR5 element. In concert with RARG, required for skeletal growth, matrix homeostasis and growth plate function (By similarity).
Subcellular location: Nucleus; Cytoplasm.
Tissue specificity: Expressed in aortic endothelial cells (at protein level).
Associated conditions: Microphthalmia, syndromic, 12 (MCOPS12).

Source: UniProtKB/Swiss-Prot P10826, release 2026_03, licensed CC BY 4.0. This is the protein’s normal biology, not evidence about post-drug syndromes; associated conditions are inherited disorders of the gene, not PFS, PSSD or PRSD.

Why its pathway is in the library

Nuclear receptors transduce steroid signals into lasting gene-expression programs; persistent receptor-level remodeling (or silencing) is a leading hypothesis for symptoms that outlast drug exposure.

Written for the whole nuclear receptors / retinoid signaling family, not for RARB specifically.

Mentioned in 0 corpus records

No corpus record names RARB directly yet. It is in the library because it sits in a pathway the corpus tracks (Nuclear receptors, retinoid signaling).

Also in steroid and nuclear hormone receptors

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Gene summary

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: Retinoic acid receptor beta
Function: Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence or presence of hormone ligand, acts mainly as an activator of gene expression due to weak binding to corepressors. The RXRA/RARB heterodimer can act as a repressor on the DR1 element and as an activator on the DR5 element. In concert with RARG, required for skeletal growth, matrix homeostasis and growth plate function (By similarity).
Subcellular location: Nucleus; Cytoplasm.
Tissue specificity: Expressed in aortic endothelial cells (at protein level).
Associated conditions: Microphthalmia, syndromic, 12 (MCOPS12).