Pathway candidateNCBI-verifiedprotein-coding

RXRG

retinoid X receptor gamma

Chromosome 1Nuclear receptors retinoid signaling

NCBI Gene: 6258 Ensembl GeneCards UniProt: P48443

Pathway candidate — not linked to PFS or PSSD by any record here

RXRG is in the library because it belongs to the nuclear receptors / retinoid signaling family. No study, report or commentary in the corpus names it, so a variant in RXRG is not, by itself, evidence of anything related to post-drug syndromes.

Gene summary

A protein-coding gene on chromosome 1 (steroid and nuclear hormone receptors). Encodes a member of the retinoid X receptor (RXR) family of nuclear receptors which are involved in mediating the antiproliferative effects of retinoic acid (RA). This receptor forms dimers with the retinoic acid, thyroid hormone, and vitamin D receptors, increasing both DNA binding and transcriptional function on their respective response elements.

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: Retinoic acid receptor RXR-gamma
Function: Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. The high affinity ligand for RXRs is 9-cis retinoic acid (By similarity).
Subcellular location: Nucleus; Cytoplasm.
Tissue specificity: Expressed in aortic endothelial cells (at protein level).

Source: UniProtKB/Swiss-Prot P48443, release 2026_03, licensed CC BY 4.0. This is the protein’s normal biology, not evidence about post-drug syndromes; associated conditions are inherited disorders of the gene, not PFS, PSSD or PRSD.

Why its pathway is in the library

Nuclear receptors transduce steroid signals into lasting gene-expression programs; persistent receptor-level remodeling (or silencing) is a leading hypothesis for symptoms that outlast drug exposure.

Written for the whole nuclear receptors / retinoid signaling family, not for RXRG specifically.

Mentioned in 0 corpus records

No corpus record names RXRG directly yet. It is in the library because it sits in a pathway the corpus tracks (Nuclear receptors, retinoid signaling).

Also in steroid and nuclear hormone receptors

All 41 genes

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Gene summary

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: Retinoic acid receptor RXR-gamma
Function: Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. The high affinity ligand for RXRs is 9-cis retinoic acid (By similarity).
Subcellular location: Nucleus; Cytoplasm.
Tissue specificity: Expressed in aortic endothelial cells (at protein level).