Large-Scale Integrative Analysis of Epigenetic Modifications Induced by Isotretinoin, Doxycycline and Metronidazole in Murine Colonic Intestinal Epithelial Cells
Eugenia Becker, Susan Bengs, Sirisha Aluri, Lennart Opitz, Kirstin Atrott, Felix Rost
Epigenomes2017
Summary (paraphrased)
Large-scale integrative analysis of genome-wide epigenetic modifications induced by isotretinoin (alongside doxycycline and metronidazole) in murine colonic intestinal epithelial cells, in the context of inflammatory bowel disease models. Demonstrates broad epigenetic remodeling following isotretinoin exposure.
Why it’s in the corpus
The only genome-wide epigenetics data on isotretinoin exposure found in this sweep — extends the epigenetic-persistence question to the post-retinoid axis, which had essentially no epigenetics coverage in v1.5. IBD-model context noted; the exposure-to-epigenetic-change link is the transferable finding.
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