Doxycycline, metronidazole and isotretinoin: Do they modify microRNA/mRNA expression profiles and function in murine T-cells?
Eugenia Becker, Susan Bengs, Sirisha Aluri, Lennart Opitz, Kirstin Atrott, Claudia Stanzel
Scientific Reports2016
Summary (paraphrased)
Examines whether doxycycline, metronidazole and isotretinoin modify microRNA and mRNA expression profiles and function in murine T-cells. Reports drug-induced changes in microRNA/mRNA regulatory networks — a microRNA-mediated (epigenetic-adjacent) layer of isotretinoin action.
Why it’s in the corpus
microRNA-mediated regulation is one arm of epigenetic control; shows isotretinoin rewires small-RNA regulatory networks — supporting the post-retinoid persistence hypothesis alongside EPI-003.
Related records
- Peer-reviewed paper
Large-Scale Integrative Analysis of Epigenetic Modifications Induced by Isotretinoin, Doxycycline and Metronidazole in Murine Colonic Intestinal Epithelial Cells
Eugenia Becker, Susan Bengs, Sirisha Aluri, Lennart Opitz, Kirstin Atrott, Felix Rost · Epigenomes
Large-scale integrative analysis of genome-wide epigenetic modifications induced by isotretinoin (alongside doxycycline and metronidazole) in murine colonic intestinal epithelial cells, in the context of inflammatory bowel disease models. Demonstrates broad…
EPI-0032017PRSDEpigenetics supplement · Oct 2026